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The JDRF was founded in 1970 by parents of children with type 1 diabetes. Since its founding, the organization states that they have awarded over $900 million to diabetes research, including more than $98 million in FY2005. Also in FY2005, the Foundation is said to have funded 500 centers, grants and fellowships in 19 countries. More than 80 percent of the Foundation's expenditures directly support research and research-related education.
Currently, the organization has six therapeutic research targets:
1. Perfecting islet transplantation - without chronic immunosuppression - to permanently restore normal blood sugar levels in people with type 1 diabetes
2. Creating safe, stable, and widely available "universal donor" sources of insulin-secreting cells for transplantation--through stem cell research and research to develop safe, human-compatible islet cells from animal sources
3. Regenerating the body's own beta cells without islet transplantation - and simultaneously inducing immune tolerance to restore normal blood sugar levels
4. Preventing type 1 diabetes by maintaining or restoring immune tolerance in new-onset patients
5. Creating novel approaches and therapeutics for predicting, preventing and reversing complications
6. Perfecting a closed-loop artificial pancreas
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