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Project Advance is part of the HIV Prevention Trials Network, which is managed by Family Health International and sponsored by the US National Institutes of Health. We are conducting a phase II clinical trial, testing the safety and acceptability of 1% tenofovir gel for vaginal use. If this study confirms that the gel is safe and acceptable, then researchers will conduct another study to test whether its use can prevent transmission of HIV infection and other sexually transmitted infections.
We are conducting a Phase II safety study of an experimental vaginal microbicide gel which may eventually help women protect themselves from the sexual transmission of HIV. This research study, called Project Advance, is designed to assess the safety and acceptability of 1% tenofovir gel for vaginal use during 6 months of use by HIV-negative, generally healthy women. A total of 200 women will be enrolled in this study, 100 women in the United States and 100 women in India. The study is sponsored by the National Institutes of Health (NIH), which is part of the federal government. Bronx-Lebanon Hospital Center is one of the two US sites. All participants will receive free physical and gynecological exams, Pap smears, and blood tests and will be compensated for their time and travel.
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